An In-Vivo Study to Evaluate the Efficacy of Padmaka (Prunus Cerasoides) as a Vedanasthapak in Supti (Numbness) Caused by Neuropathy in Wistar Rats

This research article attempts to address the main symptom of chemotherapy-induced neuropathy, which is ‘numbness’. Neuropathic pain a common side effect anticancer drugs that significantly reduces patient's quality life. work redefines term "Vedanasthapan" by explaining act regaining sensation along with its analgesic properties. study was carried out using an animal model rats prepared anti-cancer agent cisplatin. Before inducing cisplatin, normal latency periods all were noted ‘Hot plate’ method. Cisplatin given induce numbness interval week for two weeks. Four groups having six in each group labelled as – ‘control group’ treated daily diet only, ‘vehicle carboxymethyl cellulose, ‘positive control’ pregabalin, and ‘test drug ‘Padmaka’. After treatment period, tested on hot plate record time rats. All obtained data processed ANOVA test Tukey-Kramer multiple comparison test. It showed means differed from other. The mean positive control 9.06 seconds experimental 12.9 seconds, close state (7.36 seconds). While vehicle far apart. Padmaka also useful reversing cisplatin-induced numbness. Further clinical studies are needed fully understand range action.